The purpose of this study is to reveal the pathology of intestinal pathogenic E. coli (EPEC) infection in common marmosets. The survey for the various state fecal samples revealed relatively high positive rate of EPEC in bloody stool samples (53%, 52 samples) compared with those of other fecal samples (normal 13.2%; 41 samples, diarrhea 19.5%; 39 samples). Then experimental infection study was performed to 8 animals. The infection groups were set 4 animals for high dose group (108 CFU/ml) and low dose group (104 CFU/ml), respectively. As the results, all animals in the high dose group showed bloody stool till post inoculation days 2. These results suggested that EPEC is a causative agent of hemorrhagic colitis in common marmosets.
