We have been clarifying that an ectoenzyme BST-1 is expressed on various immune cells. To uncover its function in vivo, we generated BST-1 gene deficient mice and analyzed their responses against antigen immunization or challenge of microbial component, LPS. Experiments were done in specific pathogen-free condition with strict experimental conditions for keeping out environmental and other effects. As a result, there was no significant differences in antibody production against thymus-independent antigens and endotoxin shock induced by LPS injection. These results indicate that BST-1 is not required for these innate-like immune responses.
