SH3BP2 (SH3 binding protein2) is an adaptor protein, which is widely expressed in immune cells and regulates intracellular signaling such as Syk. The role of SH3BP2 in autoimmune diseases is unclear. In this study, we investigated its effects on autoimmune phenomena and organ damage using a mouse model of systemic lupus erythematosus (SLE). The results showed that SH3BP2 deficiency reduced autoantibody production, increased abnormal T cells, and subsequently suppressed organ damage in the SLE mice. These findings suggest that SH3BP2 deficiency ameliorates SLE-like lesions through suppression of dendritic cell differentiation and activation.
