It has been known that the cytokine thymic stromal lymphopoietin(TSLP) promotes the differentiation of type 2 helper T cells(Th2 cells) and induces allergic inflammations including asthma and atopic dermatitis. However, the details of its pathogenic mechanisms were still remained unclear. In this research, we found that TSLP directly stimulates CD4^+T cells and induces Th2 condition in vivo, which leads to polyclonal B cell activation and the autoimmune disease. These results would be applied to the development of novel therapies for immune diseases.
