Total synthesis and absolute stereochemistry of plakortone E.

Akiyama, Megumi; Isoda, Yuichi; Nishimoto, Masato; Narazaki, Maiko; Oka, Hiroaki; Kuboki, Atsuhito; Ohira, Susumu.

The absolute stereochem. of plakortone E (I), a cytotoxic metabolite (no data) of the Caribbean sponge Plakortis simplex, was established by the synthesis of the racemic C-8 epimer and then of plakortone E (I) itself, which was identical with the natural compound.

Tetrahedron Letters

Elsevier B.V.

47

14

2287

2290