Corticotropin-releasing factor (CRF), urocortin and urotensin I share amino acid sequences, and they inhibit food intake in mammals. The effect of these three peptides on food intake in the neonatal chick was compared. The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin I, then urocortin. Both CRF and glucagon-like peptide-1 (GLP-1) inhibit food intake of chicks, but they also produce other behaviors. In conclusion, CRF and GLP-1 interact in the chick brain, but the response depends on the behavior being measured. The involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks was examined. Endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks. Neuropeptide Y (NPY) is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It was elucidated that NPY receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick. Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue (GHS) receptor. The effect of cent
