Academic Thesis

Basic information

Name Chiba Shuichi
Belonging department
Occupation name
researchmap researcher code 5000090589
researchmap agency Okayama University of Science

Title

Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway

Bibliography Type

Author

Numakawa Tadahiro,  Odaka Haruki,  Adachi Naoki,  Chiba Shuichi,  Ooshima Yoshiko,  Matsuno Hitomi,  Nakajima Shingo,  Yoshimura Aya,  Fumimoto Kazuhiro,  Hirai Yohei,  Kunugi Hiroshi

Summary

Prolonged and intense stress chronically increases blood concentration of glucocorticoids, which in turn causes downregulation of glucocorticoid receptor (GR) in the central nervous system (CNS). This process has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). Here, we found that basic fibroblast growth factor (bFGF) increased the expression of GR in the rat cerebral cortex and cultured cortical neurons and restored the reduced GR expression caused by glucocorticoid exposure. Among intracellular signaling pathways stimulated by bFGF, extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway was responsible for the upregulation of GR. The bFGF-induced GR was functional as a transcription factor to enhance transcription of a target gene. Because high stress augments bFGF levels in the brain, it is likely that bFGF plays a compensating role for reduced GR expression after stress and thus should be studied as a therapeutic target for the treatment of MDD.

Magazine(name)

Neurochemistry International

Publisher

Volume

118

Number Of Pages

StartingPage

217

EndingPage

224

Date of Issue

2018/06

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

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DOI

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PMID

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