論文

基本情報

氏名 千葉 秀一
氏名(カナ) チバ シュウイチ
氏名(英語) Chiba Shuichi
所属 獣医学部 獣医学科
職名 講師
researchmap研究者コード 5000090589
researchmap機関 岡山理科大学

題名

Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway

単著・共著の別

著者

Numakawa Tadahiro,  Odaka Haruki,  Adachi Naoki,  Chiba Shuichi,  Ooshima Yoshiko,  Matsuno Hitomi,  Nakajima Shingo,  Yoshimura Aya,  Fumimoto Kazuhiro,  Hirai Yohei,  Kunugi Hiroshi

概要

Prolonged and intense stress chronically increases blood concentration of glucocorticoids, which in turn causes downregulation of glucocorticoid receptor (GR) in the central nervous system (CNS). This process has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). Here, we found that basic fibroblast growth factor (bFGF) increased the expression of GR in the rat cerebral cortex and cultured cortical neurons and restored the reduced GR expression caused by glucocorticoid exposure. Among intracellular signaling pathways stimulated by bFGF, extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway was responsible for the upregulation of GR. The bFGF-induced GR was functional as a transcription factor to enhance transcription of a target gene. Because high stress augments bFGF levels in the brain, it is likely that bFGF plays a compensating role for reduced GR expression after stress and thus should be studied as a therapeutic target for the treatment of MDD.

発表雑誌等の名称

Neurochemistry International

出版者

118

開始ページ

217

終了ページ

224

発行又は発表の年月

2018/06

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID