Academic Thesis

Basic information

Name Chiba Shuichi
Belonging department
Occupation name
researchmap researcher code 5000090589
researchmap agency Okayama University of Science

Title

Administration of a Selective Antagonist for Pituitary Adenylate Cyclase‐Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat

Bibliography Type

Joint Author

Author

Kaito Sato, Shuichi Chiba, Taichi Hatakeyama, Takashi Matsuwaki, Gen Watanabe, Maiko Kawaguchi

Summary

Pituitary adenylate cyclase-activating polypeptide (PACAP) affects rodents' stress-related behaviors, such as anxiety-like behavior or fear conditioning. However, previous studies have investigated the effect of intracerebroventricular, but not hippocampal, injection of this PAC1R-selective antagonist (PACAP-6-38) on anxiety-like behavior. However, it has been reported that administration of PACAP-6-38 to the dorsal hippocampus reduces the fear response in a fear conditioning test. Therefore, this study aimed to determine whether the effect of dorsal hippocampal PACAP-6-38 injection in Sprague–Dawley rats can affect anxiety-like behavior assessed by an elevated plus-maze test. As a result, rats treated with PACAP-6-38 spent longer time in open arms than those with saline, suggesting that this drug has an anxiolytic effect. In conclusion, the role of PACAP in the dorsal hippocampus can promote anxiety-like behavior.

Magazine(name)

Neuropsychopharmacology Reports

Publisher

Volume

45

Number Of Pages

1

StartingPage

e12514

EndingPage

Date of Issue

2025/03

Referee

Exist

Invited

Not exist

Language

Thesis Type

Research papers (academic journals)

ISSN

DOI

10.1002/npr2.12514

NAID

PMID

URL

J-GLOBAL ID

arXiv ID

ORCID Put Code

DBLP ID