論文

基本情報

氏名 千葉 秀一
氏名(カナ) チバ シュウイチ
氏名(英語) Chiba Shuichi
所属 獣医学部 獣医学科
職名 講師
researchmap研究者コード 5000090589
researchmap機関 岡山理科大学

題名

Administration of a Selective Antagonist for Pituitary Adenylate Cyclase‐Activating Polypeptide Receptor in the Hippocampus Causes Anxiolytic Effects in the Male Rat

単著・共著の別

共著

著者

Kaito Sato, Shuichi Chiba, Taichi Hatakeyama, Takashi Matsuwaki, Gen Watanabe, Maiko Kawaguchi

概要

Pituitary adenylate cyclase-activating polypeptide (PACAP) affects rodents' stress-related behaviors, such as anxiety-like behavior or fear conditioning. However, previous studies have investigated the effect of intracerebroventricular, but not hippocampal, injection of this PAC1R-selective antagonist (PACAP-6-38) on anxiety-like behavior. However, it has been reported that administration of PACAP-6-38 to the dorsal hippocampus reduces the fear response in a fear conditioning test. Therefore, this study aimed to determine whether the effect of dorsal hippocampal PACAP-6-38 injection in Sprague–Dawley rats can affect anxiety-like behavior assessed by an elevated plus-maze test. As a result, rats treated with PACAP-6-38 spent longer time in open arms than those with saline, suggesting that this drug has an anxiolytic effect. In conclusion, the role of PACAP in the dorsal hippocampus can promote anxiety-like behavior.

発表雑誌等の名称

Neuropsychopharmacology Reports

出版者

45

1

開始ページ

e12514

終了ページ

発行又は発表の年月

2025/03

査読の有無

有り

招待の有無

無し

記述言語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

10.1002/npr2.12514

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID