Prekallikrein Deficiency in a Dog

Takumi Okawa
Takuma Yanase
Takako Shimokawa Miyama
Hiroko Hiraoka
Kenji Baba
Kenji Tani
Masaru Okuda
Takuya Mizuno

Prekallikrein (PK) deficiency is an uncommon disorder in dogs. In this report, we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. Ely using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. The nucleotide sequence of normal canine PK cDNA was determined and compared with the genomic sequences of PK in the affected dog. The comparison revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency.

JOURNAL OF VETERINARY MEDICAL SCIENCE

JAPAN SOC VET SCI

73

1

107

111

https://www.ncbi.nlm.nih.gov/pubmed/20736516
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