論文

基本情報

氏名 下川 孝子
氏名(カナ) シモカワ タカコ
氏名(英語) Shimokawa Takako
所属 獣医学部 獣医学科
職名 准教授
researchmap研究者コード 7000022171
researchmap機関 岡山理科大学

題名

Prekallikrein Deficiency in a Dog

単著・共著の別

 

著者

Takumi Okawa
Takuma Yanase
Takako Shimokawa Miyama
Hiroko Hiraoka
Kenji Baba
Kenji Tani
Masaru Okuda
Takuya Mizuno

概要

Prekallikrein (PK) deficiency is an uncommon disorder in dogs. In this report, we describe a case of a dog that was referred for neurological defects and had a prolonged activated partial thromboplastin time (aPTT) and normal prothrombin time (PT) with no hemostatic defects. Ely using human PK-deficient plasma, the dog was diagnosed to have PK deficiency. The nucleotide sequence of normal canine PK cDNA was determined and compared with the genomic sequences of PK in the affected dog. The comparison revealed that the dog had a point mutation in exon 8 that leads to an amino acid substitution in the fourth apple domain of PK. This is the first report showing a point mutation of PK in a dog with PK deficiency.

発表雑誌等の名称

JOURNAL OF VETERINARY MEDICAL SCIENCE

出版者

JAPAN SOC VET SCI

73

1

開始ページ

107

終了ページ

111

発行又は発表の年月

2011-01

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

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ID:DOI

 

ID:NAID(CiNiiのID)

 

ID:PMID

 

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