Infectious livestock diseases, such as highly pathogenic avian influenza (HPAI) and foot-and-mouth disease (FMD), recognized as acute infection that cause tremendous damage to the livestock industry. Acute infections develop relatively early and have significant clinical symptoms, making outbreaks easily recognizable. However, HPAI and FMD outbreaks have occurred in the past in Japan, and prevention of future epidemics involves urgent of affected animals and a strict observation of standards of rearing hygiene. Conversely, chronic infections that decrease livestock productivity, such as enzootic bovine leukosis and bovine viral diarrhea, have become problematic in recent years. Generally, eradication of chronic infections is extremely difficult and requires considerable time and effort. Here we describe two cases of livestock infectious diseases occurred in the Tottori prefecture, Japan, namely an acute infection of porcine epidemic diarrhea and a chronic infection of bovine viral diarrhea, and the controls and preventions that were instituted.