論文

基本情報

氏名 中村 元直
氏名(カナ) ナカムラ モトナオ
氏名(英語) Nakamura Motonao
所属 生命科学部 生物科学科
職名 教授
researchmap研究者コード 6000014705
researchmap機関 岡山理科大学

題名

Recent advances in function and structure of two leukotriene B4 receptors: BLT1 and BLT2.

単著・共著の別

著者

Nakamura,M., Shimizu,T.

概要

Leukotriene B4 (LTB4) is generated by the enzymatic oxidation of arachidonic acid, which is then released from the cell membrane and acts as a potent activator of leukocytes and other inflammatory cells. Numerous studies have demonstratedthe physiological and pathophysiological significance of this lipid in various diseases. LTB4 exerts its activities by binding to its specific G protein-coupled receptors (GPCRs): BLT1 and BLT2. In mouse disease models, treatment with BLT1 antagonists or BLT1 gene ablation attenuated various diseases, including bronchial asthma, arthritis, and psoriasis, whereas BLT2 deficiency exacerbated several diseases in the skin, cornea, and small intestine. Therefore, BLT1 inhibitors and BLT2 activators could be beneficial for the treatment of several inflammatory and immune disorders. As a result,attractive compounds targeting LTB4 receptors have been developed by several pharmaceutical companies. This review aims to understand the potential of BLT1 and BLT2 as therapeutic targets for the treatment of various inflammatorydiseases. In addition, recent topics are discussed with major focuses on the structure and post-translational modifications of BLT1 and BLT2. Collectively, current evidence on modulating LTB4 receptor functions provides new strategies for the treatment of various diseases.

発表雑誌等の名称

Biochemical Pharmacology

出版者

203

115178

開始ページ

終了ページ

発行又は発表の年月

2022/07

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID