論文

基本情報

氏名 久楽 賢治
氏名(カナ) クタラ ケンジ
氏名(英語) Kutara Kenji
所属 獣医学部 獣医学科
職名 講師
researchmap研究者コード B000294859
researchmap機関 岡山理科大学

題名

Ozone water has antibacterial properties in dogs without skin barrier impairment

単著・共著の別

共著

著者

Matsuda A, Ano T, Nakamura Y, Itoi T, Arai K, Kutara K, Sugimoto K, Maeta N.

概要

Background: Recently, the use of disinfectants to treat bacterial skin diseases in dogs has garnered attention from the perspective of preventing the spread of antibiotic-resistant bacteria. Ozone water is a disinfectant that combines high antibacterial efficacy and safety; however, there have been no reports verifying its effects on skin barrier function in dogs.

Objectives: This study aimed to verify the antibacterial properties and effects of ozone water on skin barrier function in dogs.
Animals: Four beagles for the antibacterial test and six beagles for the barrier function test.
Materials and methods: Purified water, 3 mg/L ozone water and 0.005% and 0.05% sodium hypochlorite were used as test products. Skin bacteria were collected 5 min after a single application of each and cultured to measure the bacterial counts. Trans-epidermal water loss (TEWL) and skin surface hydration (SSH) were measured before and after application once a day for 2 weeks. Additionally, the proliferation of canine epidermal keratinocytes (CPEK) was examined after a 5-min incubation with the test products.
Results: Ozone water and 0.05% sodium hypochlorite significantly reduced the number of skin bacteria. None of the test products worsened TEWL and SSH values. Sodium hypochlorite completely inhibited the proliferation of CPEK, while ozone water did not.
Conclusions and clinical relevance: Ozone water has an antibacterial effect on canine skin comparable to that of 0.05% sodium hypochlorite, but does not inhibit keratinocyte proliferation in vitro. Thus, ozone water has the potential to be used as a safe and effective disinfectant for canine skin.

発表雑誌等の名称

Veterinary Dermatology

出版者

36

3

開始ページ

283

終了ページ

290

発行又は発表の年月

2025/06

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

doi: 10.1111/vde.13339.

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID